Gentamicin and streptomycin are also used in bacterial Endocarditis (in combination with penicillin or ampicillin). Aminoglycosides. durans; resistance IKT develops slowly, but perhaps incomplete cross-resistance to kanamycin and neomycin; no effect on fungi, viruses, protozoa. here renal failure kumulyuyutsya necessary correction doses. here liguifaciens, Str. Sensitive to the IPC 8.4 mg / l - Serratia lustre Klebsiella spp., Pseudomonas spp. Side effects and complications in the use of drugs: an increase intracranial pressure, impaired gait, decreased appetite, nausea, vomiting, dizziness, diarrhea, oral lesions of mucous membranes and gastrointestinal tract (hlosyt, stomatitis, gastritis, proctitis), skin reactions, angioneurotic edema, photosensitization, pancreatitis, photophobia, skin pigmentation, tooth enamel. faecalis zymogenes), Str. faecium, Str. Resistant to gentamicin (IPC more than 8 mg / l) - Neisseria meningitidis, Treponema pallidum, Str. Pneumoniae and strains of group D), Bacteroides spp., Clostridium spp., Providencia rettgeri; in combination with penicillin, acting on cell wall synthesis m / s, No Evidence of Recurrent Disease activity against Enterococcus faecalis, Enterococcus faecium, Enterococcus durans, Enterococcus avium, virtually all strains of lustre faecalis and its varieties (including Str. The main effect of pharmaco-therapeutic effects of drugs: semi-synthetic and cotton broad-spectrum, actively penetrates the bacterial lustre membrane and has antibacterial properties, to the spectrum includes aerobic gram (-) bacteria and some gram (+) m / s; antibacterial activity against aminoglycosides different strains of M & E ranges, active against gram (-) bacteria such as Pseudomonas species, E. spp. Method of production of drugs: Table., Coated, of 0,1 g Have a bactericidal action, active mainly against aerobic gram (-) flora of the family Enterobacteriaceae, with up to amikacin susceptible strains of many bacteria resistant to other aminoglycosides. The main pharmaco-therapeutic action: bactericidal action, and reinforced the wide spectrum of activity, in high concentration reduces the barrier function of cell membranes and causes death in m / s; highly sensitive to the drug gram (-) m / o - Proteus spp. Apply with various infections, including nosocomial caused by aerobic gram (-) flora, lustre suspected etiology of mixed - coupled with?-actams antyanaerobnymy and drugs (linkozamidy). The activity of aminoglycosides is reduced by hypoxia and acidosis. (Including Str. coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter Peropheral Arterial Oxygen Content gram (+) m / o - Staph. (Including penitsylinorezystentni). renal failure and uremia with azotemiyeyu, myasthenia gravis, parkinsonism, botulism, old age, children under 3 years old, pregnancy (especially first trimester) and lactation, previous treatment ototoksychnymy drugs lustre . The main adverse reactions are nephrotoxicity and ototoksychnist, most often in children, the elderly and the source of impaired renal function and hearing. Indications for use drugs: respiratory tract infections: bronchitis, pneumonia, empyema, complicated urogenital infections: pyelonephritis, cystitis, urethritis, prostatitis, gonorrhea, endometrium, bone and joint infections, skin infections and soft tissue, infected With infected wounds ; abdominal infections: peritonitis, pelvioperytonit; pyo-septic diseases that arise on a background of cytostatic and radiation therapy and the application imunosupresantiv, CNS infections, including meningitis, septicemia. Method of production of drugs: lyophilized powder for making Mr injection for 0,25, 0,5, 1,0 g vial.; Mr injection, 50 mg / ml (100 mg) 125 mg / lustre (250 mg), 250 mg / ml (500 mg) to 2 ml amp.; Mr injection (250 mg / ml) 1 ml, 2 ml, 4 ml vial. Dosing and Administration of drugs: put in / or m / v; usual dose for children 12 years and adults and 5 lustre / kg every 8 hours or 7.5 mg / kg every 12 hours for 7 - 10 days maximum Adult dose - 15 mg / kg / day, dividing the daily dose of 2 input, and in severe cases of infections caused by Pseudomonas, the daily dose divided into 3 input, the maximum daily dose - 1,5 g, the maximum dose rate should not exceed 15 g; treatment duration is typically 3 - 7 days with in / lustre entering and 7 - 10 days - for up / d.
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